Cagrilintide + Semaglutide

Cagrilintide + Semaglutide is a co-formulated research blend pairing two long-acting peptide analogs that act on complementary appetite-regulating pathways. Cagrilintide is a synthetic 37-amino-acid acylated analog of the pancreatic hormone amylin, built on a pramlintide-like backbone with amino-acid substitutions and an N-terminal fatty-diacid (C20) modification via a gamma-glutamic acid linker; the design is intended to extend half-life and reduce the amyloid-aggregation tendency of native human amylin while retaining amylin-receptor agonist activity. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist derived from the GLP-1 backbone, with substitutions and an acylated side chain that confer prolonged circulation. Together the two represent distinct but converging mechanisms studied in metabolic research.

In preclinical and in-vitro investigations, the amylin component has been examined for its activity at amylin and calcitonin receptors in hindbrain regions such as the area postrema, where research models associate it with modulation of food-intake signaling and gastric emptying. The GLP-1 component has been studied for incretin-pathway signaling, including effects on insulin secretion and satiety-related neural circuits in animal models. The rationale for combining them, as explored in published research, is potential additive or synergistic engagement of these separate receptor systems; controlled studies in the research literature have reported greater reductions in body weight with the combination than with either peptide alone. All such findings derive from laboratory, animal, and clinical-research settings and are reported here strictly as experimental observations.

Specifications: Cagrilintide CAS 1415456-99-3 · Molecular formula C194H312N54O59S2 · Length 37 amino acids (acylated) | Semaglutide CAS 910463-68-2 · Molecular formula C187H291N45O59 · Length 31 amino acids (acylated) · Purity >=99% (HPLC) · Form lyophilized powder · Available sizes 10 mg, 5 mg

Storage & handling: Store the lyophilized powder at -20C and protect from light. Reconstitute with bacteriostatic (BAC) water; keep the reconstituted solution refrigerated and use within a few weeks. Avoid repeated freeze-thaw cycles.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.